Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Map2k2  mitogen-activated protein kinase kinase 2   (Synonyms: MAP kinase/Erk kinase, MEK2, Prkmk2)
Results	Reference
1*	J:40857 Alessandrini A, Brott BK, Erikson RL, Differential expression of MEK1 and MEK2 during mouse development. Cell Growth Differ. 1997 May;8(5):505-11
1	J:258488 Aoidi R, Maltais A, Charron J, Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect. Sci Signal. 2016 Jan 26;9(412):ra9
1	J:112223 Bissonauth V, Roy S, Gravel M, Guillemette S, Charron J, Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development. 2006 Sep;133(17):3429-40
1	J:199705 Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O, Baccarini M, A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol. 2009 Mar;16(3):294-303
1	J:282259 Gal H, Lysenko M, Stroganov S, Vadai E, Youssef SA, Tzadikevitch-Geffen K, Rotkopf R, Biron-Shental T, de Bruin A, Neeman M, Krizhanovsky V, Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019 Sep 16;38(18):e100849
1	J:105998 Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M, Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
1	J:227204 Li A, Tian X, Zhang X, Huang S, Ma Y, Wu D, Moeckel G, Somlo S, Wu G, Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice. Am J Pathol. 2015 Oct;185(10):2843-60
1	J:147279 Nadeau V, Guillemette S, Belanger LF, Jacob O, Roy S, Charron J, Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development. 2009 Apr;136(8):1363-74
1	J:170095 Urosevic J, Sauzeau V, Soto-Montenegro ML, Reig S, Desco M, Wright EM, Canamero M, Mulero F, Ortega S, Bustelo XR, Barbacid M, Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5015-20
1	J:295894 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D, Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Sep 2;147(17):dev185678
1	J:230714 Xing L, Larsen RS, Bjorklund GR, Li X, Wu Y, Philpot BD, Snider WD, Newbern JM, Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex. Elife. 2016;5:e11123
1	J:163721 Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B, E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010 Jul 1;120(7):2474-85
1	J:121660 Zhong J, Li X, McNamee C, Chen AP, Baccarini M, Snider WD, Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci. 2007 May;10(5):598-607